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Description
Special populations: specific considerations when switching Women of reproductive age Both semaglutide and tirzepatide can affect fertility and are not recommended during pregnancy or breastfeeding
But those taking a GLP-1 for weight loss may think about reducing their dose or even stopping completely once they reach their goal weight
Stability testing depth Brand-name stability testing follows ICH Q1A guidelines, involving multiple storage conditions (25 degrees Celsius/60% relative humidity for long-term, 40 degrees Celsius/75% relative humidity for accelerated), multiple time points (0, 3, 6, 9, 12, 18, 24 months), and multiple analytical methods (HPLC for potency, size exclusion chromatography for aggregation, pH measurement, visual inspection, and more)
Rapid weight loss may result in telogen effluvium and temporary hair shedding
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In major trials, tirzepatide produced higher average weight loss, while semaglutide remains the most familiar GLP-1 benchmark
