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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the management of obesity in adults without diabetes: a network meta-analysis of randomized clinical trials

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The excess blood sugar can also lead to dysfunction of the heart muscle directly and cause it to become stiffer and pump blood less efficiently. Tirzepatide works by mimicking two natural gut hormones that are released after eating, leading to more weight loss and better control of the major drivers of cardiovascular disease: blood sugar, blood pressure, and cholesterol, added DesJardin

Potency degrades over time, meaning your calculated dose may deliver less active tirzepatide than expected

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Christine Smith-Reed had tried it all: a dietitian, grueling workouts, even weight-loss surgery in Mexico