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77 Pharmacological inhibition of PDEs could theoretically sustain or elevate cAMP levels, potentially enhancing GLP-1 RA signaling

Psychiatry 24, 4657

Theyre legal for research purposes but not approved for human consumption

Tirzepatide mimics this hormone but lasts an entire week, creating sustained appetite suppression and blood sugar control that natural GLP-1 could never achieve

Many plaintiffs also say they werent informed of potential side effects

The use of GLP-1 analogues in such cases could be a pragmatic approach based on prescribing information, available clinical evidence and clinical sense of physicians (Grade D
