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Authors contributions Drafting the manuscript, creating figures and tables (WMW), and critically revising the document for important intellectual content (LGL)

The tirzepatide before and after results and comparable retatrutide data suggest that the glucagon receptor component produces additional fat loss beyond what dual agonist therapy achieves, particularly for visceral fat

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thyroid cancer or hyperthyroidism, gastroparesis, pancreatic cancer or pancreatitis, MEN2 syndrome, or inflammatory bowel disease)

The primary risks include gastrointestinal side effects (nausea, vomiting, diarrhoea), undesirable weight loss in patients at risk of malnutrition, delayed gastric emptying that may impair levodopa absorption, and rare but serious complications such as pancreatitis and dehydration leading to acute kidney injury