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A key point is that the activation of GLP-1R can produce specific effects on different organs by addressing age-related diseases in various manners, such as enhancing cognitive function and addressing vascular issues caused by age-related brain changes, while simultaneously raising the likelihood of renal dysfunction in aging organs

N Engl J Med 2008;358:25452559

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11,12 While use of GLP-1RA for cardiovascular benefits has been increasing, whether GLP-1RA can be used for arrhythmia prevention remains unknown because none of cardiovascular outcome trials for GLP-1RA studied AF as a primary outcome