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For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients

Persistent or worsening fatigue despite treatment warrants medical review to investigate other potential causes such as anaemia, thyroid disorders, sleep apnoea, depression, or medication side effects

[DOI] [PubMed] [Google Scholar] 143.Ghusn W, Hurtado MD

Cell Rep 21:11601168

Implications for employers: Although almost half of employers stated that they were interested in the potential for compounded GLP-1 medications, according to WTWs 2025 Best Practices in Healthcare Survey, only 7% said they were very interested, and there has been very little employer uptake of compounded medications

Es importante sealar que su uso en prediabetes no est aprobado por la FDA (uso fuera de indicacin)