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For instance, those with GI disease, a history of gallbladder disease, a high risk for pancreatitis, or kidney and liver issues would likely be advised not to take retatrutide

The studies were conducted in a variety of countries (USA, Sweden, Germany, Denmark, and China), which increased the generalizability of the findings across populations

That's what Phase 3 trials are designed to assess

NICE NG28 Targeted CGM for T2D NICE takes a more targeted approach: offer isCGM to adults on multiple daily insulin injections who have recurrent or severe hypoglycemia, impaired hypoglycemia awareness, or a disability restricting standard finger-prick monitoring

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Retatrutide's phase 2 obesity data (around 24% at the top dose) edged tirzepatide's SURMOUNT-1 result (about 21%), but they come from different trials, not a head-to-head, and retatrutide is not approved