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Interestingly, wild-type mice had lower levels of IL-10 in the brain, whereas DPP4 mice had higher levels, suggesting a potential role of DPP4 in modulating neuroimmune responses during colitis onset

Tirzepatide was reported in only one study, and individual drugs could not be analyzed separately

Diphtheria toxin-induced ablation of preproglucagon-positive neurons in the NTS demonstrated that this small population of neurons is the primary source of endogenous GLP-1 in the brain [90]

Early trials have provided implication of the neuroprotective benefits of pioglitazone, which are potentially mediated by its anti-inflammatory and insulin-sensitizing effects

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