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Conclusions GLP-1 analogues are an effective treatment for weight loss, and the addition of bupropion/naltrexone is associated with greater weight loss including in patients who are initially non-responsive to GLP-1 analogues

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But for many, especially people without qualifying conditions, it makes sense to be extremely cautious: Because Medicare right now will pay only in certain cases (not for weight loss alone)

Costcos executive members and Costco Citibank Visa card holders will get an additional 2 percent discount, Novo Nordisk said