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The pathophysiology of lipedema remains incompletely understood, though current evidence suggests involvement of hormonal factors, genetic predisposition, lymphatic dysfunction, and chronic inflammation

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Journal of Clinical Endocrinology and Metabolism 10318041812

(2025) ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease Lamija Ferhatbegovi, et al

Some providers may discuss continuation on a case-by-case basis when weight management is medically urgent and safer alternatives are unavailable