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Those medications work through fewer receptor pathways and have lower maximum efficacy in clinical trials

That is the core principle of our GLP-1 Body Blueprint

Here's how our clinical team thinks about it, and what we actually recommend

Pfizers lotiglipron was scrapped in June 2023 over transaminase elevations in Phase I studies

Progesterone: For oral progesterone (e.g., Utrogestan), absorption may also be reduced when starting or increasing Mounjaro or Wegovy

Patients in the PIONEER 6 trial had the same cardiovascular risk profile as those in the SUSTAIN 6 trial [30]