glp 1 joint pain GLP-1 agonists linked to significantly lower long-term risk of knee replacement Semaglutide helps with Knee Pain?

They are classified as dietary supplements rather than pharmaceuticals, which means they are not subject to the same regulatory scrutiny or clinical trial requirements

However, none are yet approved by the EMA or FDA specifically for the treatment of obesity, though trials in obese people without T2D have shown promising results [61]

Kim et al

Those who shouldnt take GLP-1 agonists include people who: are pregnant, nursing, or planning to become pregnant have a history of thyroid cancer or pancreatitis are allergic or sensitive to any of the GLP-1 medications have multiple endocrine neoplasia (MEN) syndrome type 2 Weight loss medications are not recommended for people with past or active eating disorders

J Clin Invest 124: 2456-2463, 2014

The confirmatory secondary endpoints included the change in the 6-min walking distance, a hierarchical composite of death and heart failure events