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Additionally, the cardiac magnetic resonance substudy of the SUMMIT trial revealed that compared with placebo, tirzepatide treatment of obese HFpEF patients reduced the LV mass and paracardial adipose tissue volume, with the changes in the LV mass paralleling the degree of weight loss [166]

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Research has shown that it can simultaneously support fat loss while protecting lean mass, often considered a "holy grail" for dieters

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Losing more than a few pounds per week could take a serious toll on your body: Rapid weight loss can also amplify feelings of tiredness, he adds, especially in the early stages of taking the medication. There are a few ways to prevent yourself from feeling tired while taking semaglutide There are a few ways that you can prevent yourself from feeling tired while taking semaglutide