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By combining data from observational and Mendelian randomization (MR) studies, we aimed to investigate whether GLP-1 RAs decrease the risk of DR

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However, the existing evidence is limited by small cohort sizes, heterogeneous patient populations, and confounding effects of concurrent therapies, limiting its generalizability

Your doctor consultation ensures your progress is regularly monitored, your treatment stays safe, and any adjustments needed over time are guided by medical expertise

Combining spironolactone with GLP-1 medications like semaglutide requires careful medical oversight due to potential effects on kidney function and electrolyte balance