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doi: 10.1016/j.cmet.2021.12.005 67 KnerrPJMowerySADourosJDPremdjeeBHjllundKRHeYet al

2 However, controversy exists regarding the selection of second-line treatment in patients optimized on MET but not achieving glycemic targets, with contraindications to use of MET, or unable to tolerate MET

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Several clinical trials implemented a combination of semaglutide treatments with sulfonylurea, sitagliptin, basal insulin, metformin, or other antidiabetic drugs (Table 3)

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