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Prescription Pain Medications and Semaglutide Interactions Opioid pain medications such as codeine, tramadol, and stronger opioids should be used cautiously with GLP-1 therapy due to overlapping effects on the central and enteric nervous systems
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CagriSema has the stronger evidence base with completed phase 3 REDEFINE trials showing 20.4% weight loss, and is closer to potential approval
