retatrutide phase 2 nejm 2023 obesity trial jastreboff GLP-1 Medications for Weight Loss: Semaglutide vs Tirzepatide vs Retat – Revolution Health & Wellness Phase 2 Trial of Retatrutide

For the first time, a non-invasive pharmacological agent approaches or exceeds the least aggressive bariatric surgery

The twist

Regulators protecting patients in the news In a January warning letter to an Arizona facility that produces kids' bubblegum toothpaste, the FDA cited significant CGMP violations, including inadequate controls to prevent cross-contamination from potent ingredients, insufficient cleaning validation, release of drug products without proper laboratory testing, and a lack of effective quality unit oversight

Weight loss medications may not be appropriate for every patient

The starting daily dose for the Wegovy pill is 1.5 milligrams, which can be ramped up to the maximum dose of 25 milligrams over 90 days

Recommended options: Sculptra or Ellans for long-term collagen stimulation