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Further, E9 of GLP-1 forms electrostatic and hydrogen bond interactions, respectively, with Y 152 (TM1) and R 190 (TM2), which are crucial for GLP-1R activation and signaling

Maturitas 2019;126:69-72

This releases the Notch intracellular domain (NICD), allowing its translocation to the nucleus where it promotes expression of the lst-1 and sygl-1 stemness genes, and acts as the niche signal allowing GSCs to proliferate 15,16,17,18

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