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These effects are observed both as direct GLP-1R-mediated actions and indirectly through weight loss and improved insulin sensitivity

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Glad Dr DeFronzo brought up Pioglitizone( Actos) as being under appreciated

American Heart Association: Cholesterol Medications

N Engl J Med 355(22):22972307 Cusi K, Orsak B, Bril F, Lomonaco R, Hecht J, Ortiz-Lopez C et al (2016) Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus
