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Inphase 3 clinical trials (SURPASS 1-5), the dose-dependent efficacy and safety of tirzepatide were assessed by once-weekly subcutaneous injection (5mg, 10mg, and 15 mg), as monotherapy or combination therapy, in individuals with T2DM

Here, we aimed to provide an overview of retatrutide's safety and effectiveness in treating obesity.

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The analysis showed significantly greater WL in the GLP-1RAs group compared to placebo (SMD=0.82, 95% CI 0.23 to 1.42)