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DOI: This research is funded by the U.S

(5) Bitter taste inhibition: Macrocyclic encapsulation technology utilizing tetraanionic hosts enhances BBR solubility and masks bitterness via parallel-arranged aromatic compound inclusion [197]

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In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance (62) a therapeutic infusion of GLP-1 at a pharmacological dose can restore -cell insulin secretion responsiveness to glucose levels comparable to those observed in nondiabetic individuals (62)

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The new RIA provided a crucial tool for clarifying the physiological effect of glucagon and to measure the concentration of the peptide in blood and tissue samples (Unger)