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In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain

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When triggered, they degranulate, releasing their contents into surrounding tissue

Instead of trying to eat three normal-sized meals that your suppressed appetite will not allow, switch to smaller, more frequent eating occasions

Hydrate wisely Drinking fluids between meals instead of with them may help with nausea

Monitor the effects of oral medications concomitantly administered with Ozempic