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ACTRN12624000111572)

10.1371/journal.pone.0181218 [EL 2

How Semaglutide Changes Endurance Fuel Utilization Semaglutide activates GLP-1 receptors in the hypothalamus and gastrointestinal tract, triggering two simultaneous effects that directly impact marathon performance: appetite suppression through leptin potentiation and delayed gastric emptying via reduced smooth muscle motility

People in the study also saw improvements in waist size, blood pressure, and cholesterol, markers that matter for long-term health

However, addressing hyperuricemia early could help prevent complications
