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Highintensity interval training is effective and superior to moderate continuous training in patients with heart failure with preserved ejection fraction: a randomized clinical trial

Obes Rev (2022) 23:e13372

Sakaue S: OR = 0.78, 95% CI [0.760.80]
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Treatment persistence has improved compared to earlier GLP-1 formulations, though discontinuation rates remain significant, often due to gastrointestinal side effects or cost concerns