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An Overview of Incretin-Based Therapy Incretins are a class of hormones secreted by the gastrointestinal tract in response to oral carbohydrate intake to help regulate glucose metabolism

Elevated intracellular cGMP levels activate protein kinase G type 1 (PKG-1), which lowers cytosolic calcium concentrations and activates calcium-dependent potassium (KCa) channels, favoring VSMC hyperpolarization and smooth muscle relaxation [22,23]

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Numerous studies have demonstrated that for every 10% increase in body mass index (BMI), the risk of developing OSAS increases by nearly six-fold (7, 8)

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therefore, lowering the dose of insulin or insulin secretagogue should be considered