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Langer and colleagues make a serious case that it isn't that hepatic and intramuscular fat mobilization, glycogen depletion, and fluid shifts are being misclassified as muscle loss in the trial literature, with the mismeasurement potentially substantial

A more accurate frame is: berberine is a metabolic-support supplement that may help some people a little, especially if blood sugar/insulin resistance is part of the picture

doi: 10.2337/diabetes.54.8.2277

Thanks to its low anti-nutritional factor content, it is well tolerated

This is a composite, and individual results vary widely but it captures a pattern I now see often enough that I ask about metabolic inflammation at nearly every RA visit

What GLP-1 Injections Are and How They Work GLP-1 stands for glucagon-like peptide-1, a hormone your body naturally produces after eating