glp 1 agonist delayed gastric emptying Interleukin-6 Delays in Humans with Direct Effects on Glycemic Control Liraglutide, semaglutide, and tirzepatide delay

Sci Transl Med 9(404):eaan0972 Mitchell JL et al (2023) The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial

25.5%), only half received treatment intensification ( n = 483

Obesity and severe obesity prevalence in adults: United States, august 2021august 2023

[4] SUSTAIN-6 (semaglutide) : In 3,297 high-risk patients with type 2 diabetes, once-weekly semaglutide reduced major cardiovascular events by 26% and stroke by 39% over two years

These metabolites have direct or indirect protective effects on the cardiovascular system due to their biological activity, which can lower intravascular oxidative stress, inhibit hepatocyte gluconeogenesis and oxidative stress, boost cardiomyocyte activity, encourage vasodilation, and improve cardiac function [126], [127], [128]

Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: incretin actions beyond the pancreas