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GLPs are a powerhouse for regulating blood sugar and quieting "food noise," however they slow down digestion which can be a massive reflux trigger

In brief, patients were adults who had been diagnosed with T2D 90 days before screening, had baseline HbA 1c above target (7.010.5% [5391 mmol/mol] in PIONEER 3 and 7.09.5% [5380 mmol/mol] in PIONEER 4, 5, 7 and 8) and were receiving stable doses of glucose-lowering background medication(s)
In a large study of over 18,000 patients, rates of gastrointestinal side effects were similar between tirzepatide and semaglutide users, with no significant difference between the drugs
But for some, it remains disruptive enough to cause dose reductions or treatment discontinuation

Overweight Without Comorbidity: Not Eligible With Weight-related Conditions: BMI 27 Obese Without Comorbidity: BMI 30 With Weight-related Conditions: BMI 30 Do You Need to Have at Least One Weight-Related Health Condition to Qualify for Semaglutide