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The number of reported events for these medicines increased over the study years, which may be due to their increased use

Major risk factors include: Smoking : The most significant modifiable risk factor, approximately doubling pancreatic cancer risk Chronic pancreatitis : Particularly hereditary pancreatitis, which substantially increases lifetime risk Family history : Hereditary syndromes and familial clustering account for approximately 10% of cases [18] [19] Diabetes mellitus : Long-standing type 2 diabetes is associated with increased risk, though new-onset diabetes may occasionally be an early manifestation of pancreatic cancer Obesity : Elevated body mass index is independently associated with increased risk Age : Incidence rises sharply after age 50, with median diagnosis around 70 years [18] The relationship between diabetes and pancreatic cancer is complex and bidirectional