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7 Conclusion Current evidence supports the efficacy of GLP-1 RAs in managing T2DM and obesity, with additional benefits for cardiovascular and renal health

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With regard to safety, both metformin and GLP-1 RAs are associated with gastrointestinal (GI) adverse events

GPR43 gene knockout (FFAR2 / ) mice exhibited a reduction in GLP-1 secretion in vivo and in vivo 16