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GLP-1 RAs could inhibit the expression of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) in human vascular endothelial cells in vitro, which had a protective effect against endothelial cell dysfunction (ECD) in the early stages of diabetic vascular disease [32] and might explain the lower incidence of background and severe nonproliferative DR among individuals who used GLP-1 RAs

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doi:10.1001/jama.2023.24945 43

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16-18 Nausea is the most frequently reported AE among GLP-1 RAs, with rates ranging from 20% to 40% depending on the agent and dose

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95% CI 0.1286.09

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(Although Qsymia also contains phentermine, the dose of phentermine in Qsymia is lower than the typical dose used in phentermine alone

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Judicial Panel for Multidistrict Litigation (JPML) transferred cases involving harms related to non-arteritic anterior ischemic optic neuropathy (NAION) to a new MDL

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