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GLP-1 RAs could inhibit the expression of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) in human vascular endothelial cells in vitro, which had a protective effect against endothelial cell dysfunction (ECD) in the early stages of diabetic vascular disease [32] and might explain the lower incidence of background and severe nonproliferative DR among individuals who used GLP-1 RAs

doi:10.1001/jama.2023.24945 43

16-18 Nausea is the most frequently reported AE among GLP-1 RAs, with rates ranging from 20% to 40% depending on the agent and dose

95% CI 0.1286.09

(Although Qsymia also contains phentermine, the dose of phentermine in Qsymia is lower than the typical dose used in phentermine alone

Judicial Panel for Multidistrict Litigation (JPML) transferred cases involving harms related to non-arteritic anterior ischemic optic neuropathy (NAION) to a new MDL
