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ANALYSIS METHODOLOGY For a deeper understanding of where off-label GLP-1 uses are emerging, Storyful Intelligence analyzed 29.9k mentions across conversations on X, Facebook, Reddit, and Instagram, from February 1, 2024, to March 24, 2025

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Previous studies have shown that activation of the glucagon-like peptide-1 receptor (GLP-1R) leads to anti-inflammatory and anti-apoptotic effects

Preclinical models, clinical trials and real-world observational studies strongly support the hypothesis that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors may confer neuroprotective benefits