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In chronic form, however, it can persist without an external cause and lead to organ damage
Fat-Focused Weight Loss Clinical body-composition analyses show that retatrutide promotes greater fat mass loss with relative preservation of lean muscle, supporting healthier body recomposition rather than simple weight reduction

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A study by Feng et al
The net effect on overall comfort can vary, for example, if diarrhoea was the more troublesome symptom for you, semaglutide might feel like a net win despite some constipation, or vice versa
