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I graduated from medical school very young in 1975, so I can honestly say that these are the medications that have had the greatest benefits for obesity and the associated complications. Yet, GLP-1 drugs are not without side effects

Because the medication slows digestion, fatty foods sit in the stomach longer and are the number one trigger for severe nausea and vomiting, she explains

Metformin alone rarely causes hypoglycemia, but when paired with semaglutide, which increases insulin secretion, your risk of blood sugar dropping too low increasesespecially if you're also taking insulin or sulfonylureas

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Matthew Hayes, a nutritional neuroscientist at the University of Pennsylvania, who has studied GLP-1 and other gut hormones since 2006, explains that these drugs work partly because they slow digestion and modulate glucose levels