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Similarly, many studies show no effect, or even improved mood in people taking GLP-1 RAs

The development of GLP-1R, GIPR, and GCGR poly-agonists marks a new era in obesity pharmacotherapy

Subjects of the randomized controlled trial (RCT) are usually selected from relatively healthy individuals, patients with a history of MTC or pancreatitis may be excluded, RCT are not long enough to cause cancer AEs, and no RCT has tumor events as the primary outcome