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Most GLP-1 RAs are injected, although an oral formulation of semaglutide is now available (11)

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Common Side Effects The most common side effects experienced by patients include: Nausea (typically mild to moderate and often improving over time) Diarrhea (usually temporary as your body adjusts to the medication) Less Common Side Effects Vomiting Constipation Abdominal pain Headache Fatigue Upset stomach Dizziness Bloating Belching and gas Gastroenteritis (stomach flu) Heartburn Upper respiratory symptoms (runny nose, sore throat) Rare Side Effects Burning sensation in the chest or stomach Indigestion Stomach upset Tenderness in the stomach area Most side effects are mild to moderate and tend to decrease over time as your body adjusts to the medication

Researchers are investigating Retatrutide's potential effects on: Appetite regulation Body weight management Energy expenditure Metabolic health Body composition Its triple-agonist design represents a different approach compared with peptides that target only one metabolic pathway

Once you take semaglutide, it enters your bloodstream and binds to GLP-1 receptors found in various parts of your body, including the pancreas, stomach, and brain