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Some preclinical and emerging research suggests that GLP-1 may have indirect effects on mood and behaviour through potential influence on: Hypothalamic circuits that regulate both feeding behaviour and emotional responses Reward pathways in the brain, potentially affecting dopaminergic systems Inflammatory markers and metabolic health, which may influence mental wellbeing These potential indirect pathways are still being investigated, and their clinical relevance in humans remains unclear

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Ozempic Safety Timeline: FDA Warnings, Studies, And Lawsuits December 2025: Multidistrict litigation was formed for claims that Ozempic caused patients to develop NAION (non-arteritic anterior ischemic optic neuropathy)

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