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Compounded oral semaglutide is made in response to FDA-recognized shortages of the commercially available drug

The mechanism likely involves improved vagal tone and reduced sympathetic nervous system activationchanges that naturally calm thermoregulatory overactivity

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Real-world data suggests slower dose escalation, regardless of medication choice, reduces side effect severity

Patients should attend regular diabetes or weight management reviews and report any concerns about efficacy, side effects, or injection technique to their healthcare team for ongoing optimisation of therapy

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