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Description
From there, patients continue to inject a weekly maintenance dose

Exendin-4 induced retching-like behavior mediated by postsynaptic effect via AMPA receptors in the area postrema of mice
Serious adverse effects are rare but require immediate medical attention

These changes are expected and reflect the loss of the medicines effect, not dependence

While most tirzepatide-related aches resolve within the first 2-4 weeks, ongoing discomfort may indicate an unrelated condition, a nutrient deficiency that has not been addressed, or a need for protocol adjustments

Gastrointestinal autoimmune conditions Patients with celiac disease, Crohn's disease, ulcerative colitis, or autoimmune hepatitis face particular challenges with tirzepatide
