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Patients who microdose through the early weeks typically report much less GI distress at therapeutic doses compared to those who started at 2.5 mg immediately

Primary read-outs are expected over the coming years

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On the other hand, insulin promotes pancreatic cancer initiation and sustains PDA development by eliciting tumorigenic inflammation, regulating lipid and glucose metabolic reprogram, overcoming apoptosis through the crosstalk with IGF-1, stimulating cancer metastasis, and activating tumor microenvironment formation (inflammation, fibrosis, and angiogenesis)

The right choice depends on your insurance situation, budget, and preferences