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GLP-1 may affect systemic energy metabolism by regulating adipocyte development, accelerating plasma clearance of glucose and triacylglycerol-derived fatty acids, improving insulin signaling, and stimulating thermogenesis in brown adipose tissue (BAT) [40-45]

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The growing prevalence of obesity and associated comorbidities, such as diabetes and cardiovascular disorders, has propelled the demand for GLP-1 receptor agonists

Novak P, Pimentel Maldonado DA, Novak V

Finally, neither trial looked at lifestyle alternatives like adjusting diet and exercise

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