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In contrast, the metabolic profile PNA mice was unaffected after intervention with lower doses of the dual- and triple-agonists, as well as with metformin (Fig

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doi: 10.1038/bjp.2008.100 97 WebsterLRReisfieldGMDasguptaN

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Consequently, GLP-1 is effectively degraded upon secretion from enteroendocrine cells and when released into the circulation, resulting in GLP-1 736 having a circulatory half-life of approximately 1 min 7,8

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