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However, when combined with insulin or sulfonylureas in research models of diabetes, hypoglycemia risk increases and dose adjustments of background therapies are typically recommended

Strategies to mitigate this include gradual dose tapering rather than abrupt cessation, concurrent development of sustainable dietary and exercise habits, and potentially transitioning to lower maintenance doses rather than complete withdrawal

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Genetic Factors That Influence Your Personal Response Your genes control how efficiently your body produces and responds to GLP-1 and GIP hormones