glp-1 and perimenopause Agonists in Perimenopause: Unique Risks Potential Opportunities Let's talk about GLP-1 medications

Ania Jastreboff , MD, PHD, is an adult and pediatric endocrinologist at the Yale School of Medicine in New Haven, Connecticut

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It is a once weekly subcutaneous injection and is available in doses that begin at 0.25 mg and titrate up to 2.0 mg

Additionally, rapid weight loss in general can promote breakdown of both fat and muscle unless muscle is actively preserved through nutrition and resistance training

Date: November 16, 2025 Source: Cochrane Summary: GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility

Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH