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Novos estimates help bracket the range: Floor (~15%): In early 2025, Novo said ~1M U.S
The highest dose of semaglutide for weight loss is 2.4 mg once weekly
Ladage et al., 2013
Meta-analyses also affirm GLP-1RAs benefit in heart failure with preserved ejection fraction (HFpEF) [59]
This change is often subtle at first
