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Mechanisms of Action and Benefit Biological, Physiological, and Molecular Considerations Glucagon-like peptide 1 (GLP-1) is primarily secreted by enteroendocrine L-cells in the intestine, pancreatic -cells, and the central nervous system (CNS) [26]

Moreover, the leptin surge after treatment cessation is an underestimated driver for the weight rebound, underscoring that a reduction of leptin per se (i.e., even prior to any weight loss) is a direct driver of reduced fat mass

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The active ingredient is identical, but manufacturing , testing , storage , and delivery create meaningful differences in predictability , safety , and results

Each medication has its recommended starting dose, which is usually adjusted gradually