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The SURMOUNT-5 trial directly compared these two compounds, and Tirzepatide produced significantly greater weight reduction across all measured timepoints

Sources Tirzepatide Once Weekly for the Treatment of Obesity (June 4, 2022) Fda Clarifies Policies For Compounders As National Glp-1 Supply Begins To Stabilize (April 28, 2025) Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial (March 23, 2019) Lilly's Zepbound (Tirzepatide) Superior To Wegovy (Semaglutide) In Head-To-Head Trial Showing An Average Weight Loss Of 20.2% Vs

Ozempic is also FDA-approved to reduce cardiovascular risk

Cardiovascular Endocrinology & Metabolism, 6(2), 5361

As a twincretin, tirzepatide activates two important receptors: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)