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This provides long fasted periods potentially enhancing insulin sensitivity and fat oxidation

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Proof of principle for the synergistic interaction of these 2 systems also in males comes from data showing that GLP-1-estrogen conjugate applied peripherally or directly to the CNS has superior effects of body weight loss, fat mass, or food-motivated behavior suppression in males (41, 42)

Totowa, US: Humana Press

The difference stems from direct appetite circuit engagement rather than metabolic optimization alone

* Your body does not naturally produce the enzyme needed to digest many plant-based foods