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2017;33:e2924

In all clinical trials, participants who lost the most weight paired medication with intensive diet and exercise modifications

Keywords: bile stasis, cholecystokinin, FXR, gallstones, GLP-1 receptor agonists, TGR5 Plain language summary GLP-1 receptor agonist medications and gallbladder disease: understanding the mechanisms and what it means for patients Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are commonly used to help people with type 2 diabetes and obesity by improving blood sugar control and promoting weight loss

Semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) require a prescription

Clinical trials show prescription semaglutide produces 9-15% weight loss on average, while OTC supplements lack published human trial data demonstrating comparable results