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While the type of GLP-1 RA formulation or duration of treatment did not affect gastric emptying (scintigraphy), it was significantly increased in obese patients with BMI 30 kg/m 2 ( p = 0.018)

Lipopolysaccharide binds pattern-recognition receptors such as TLR4, triggers innate immune signaling, and releases inflammatory mediators including TNF-alpha

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

This integrative strategy could offer new avenues for managing treatment-resistant obesity-related OSAS

Its particularly effective for people with a higher starting weight or those who havent responded well to other treatments

Patricia Murphy contributed to the conception and design of the manuscript